CD8A and neoplasm: For instance, regulatory T cells (Tregs) and tumor associated macrophages (TAMs) are associated with pro-tumor functions (De Palma & Lewis, 2013; Nishikawa & Sakaguchi, 2014; Noy & Pollard, 2014), but CD8+ T cells are associated with improved clinical outcomes and better responses to immunotherapy (Tumeh et al., 2014).