Notably, growths of all KRAS-mutant cells (A549, H358, H460, and H1373) were attenuated by PIERCE1 KD (Fig. 1b–d), while half of KRAS WT lung cancer cell lines (H3122, H226, HCC827, PC-9, H1299, and Heas-2B) were responsive to PIERCE1 depletion. This evidence concerns the gene PIERCE1 and lung cancer.