Moreover, an investigation of overall survival in specific types of lung cancer revealed more evident differences between low and high PIERCE1 expression groups (HR = 1.98) in lung adenocarcinomas, while no differences were detected in the case of lung squamous-cell carcinomas (Supplementary Fig. 1b, c), suggesting a link between PIERCE1 expression and survival rates particularly in lung adenocarcinomas. Here, PIERCE1 is linked to squamous cell lung carcinoma.