To validate the clinical relevance of PIERCE1 depletion in KRAS-mutant lung cancers, we used a urethane-induced lung cancer model system that exhibits Q61R mutation in KRAS protein in 94% of all PIERCE1 KO mice by administering urethane, and these mice were examined for 3 months after initial injection [38]. This evidence concerns the gene PIERCE1 and lung carcinoma.