CYP4B1 and hypospadias: We identified a significant causal effect of methylation at cg04714159 on hypospadias, as well as potential causal effects of multiple members of the cytochrome P450 family of enzymes in this region (CYP4A11, CYP4A22, CYP4B1, CYP4X1, CYP4Z2P; Fig. 3).