This region on chromosome 19 is characterized by clusters of sialic acid-binding Ig-like lectin (SIGLEC) and kallikrein (KLK) genes, among which we identified likely causal relationships with hypospadias (CD33/SIGLEC3, SIGLEC5, SIGLEC7, KLK5, KLK7, KLK10, KLK13, and KLK14). This evidence concerns the gene KLK5 and hypospadias.