We identified a significant causal effect of methylation at cg04714159 on hypospadias, as well as potential causal effects of multiple members of the cytochrome P450 family of enzymes in this region (CYP4A11, CYP4A22, CYP4B1, CYP4X1, CYP4Z2P; Fig. 3). The gene discussed is CYP4A22; the disease is hypospadias.