We considered gene mutation and gene expression data of independent DNMT3A-mutated AML patients from the German-Austrian AML Study Group34,43–45 to analyze whether the characteristic gene mutation and expression profiles that distinguished short- and long-lived DNMT3A-mutated TCGA AML patients are also of potential prognostic relevance for other patients. The gene discussed is DNMT3A; the disease is acute myeloid leukemia.