By screening 130 individuals affected with NSHL using our in-house targeted exome sequencing, it revealed another family (Family-2) with a sporadic patient who had a heterozygous MITF mutation, c.1021C>T: p.Arg341Cys of isoform MITF-A, and a heterozygous GJB2 mutation, c.109G>A: p.Val37Ile (Fig. 2). The gene discussed is MITF; the disease is nodular sclerosis classical Hodgkin lymphoma.