Here we tested three different human transgenes encoding for: α-L-iduronidase (IDUA; Hurler syndrome, OMIM #607014), α-galactosidase (GLA; Fabry disease, OMIM #301500) and lysosomal acid lipase (LAL; Wolman disease, OMIM #278000). The gene discussed is GLA; the disease is Fabry disease.