In a preclinical study, anti-F(ab′)2-autoantibodies caused severe thrombocytopenia in 5 of 18 cynomolgus monkeys by reacting with a F(ab′)2 therapeutic mAb27, and a clinical trial was terminated due to cytokine release initiated by autoantibodies against the Fab region of an anti-TNFR1 antibody28. The gene discussed is TNFRSF1A; the disease is Thrombocytopenia.