S-CRS, the most common AE associated with CAR T-cell treatment, is characterized by fever, hypotension, hypoxia and increased release of inflammatory cytokines,89,90 including IL-1, IL-6, IFN-γ, TNF-α, GM-CSF, MIP-1α, MCP1 and IL-10. The gene discussed is IFNG; the disease is congenital rubella syndrome.