SOX2 and esophageal cancer: For example, the methylation of the SOX2 promoter by DNA methyltransferase (DNMT) inhibits SOX2 transcription, and this hypermethylation of SOX2 appears to be a critical epigenetic event, leading to SOX2 silencing in several types of human cancers, including esophageal cancer,44 gastric cancer (GC),45 and endometrial cancer.46 However, the loss of SOX2 in these subgroups of cancers is associated with the worse clinical characteristics and poor prognosis,44–46 which is an interesting subject for future investigation.