In the research article “Long-term expansion of epithelial organoids from human colon, adenoma, adenocarcinoma, and Barrett’s epithelium” (2), Clevers’ group identified the essential factors necessary for ex vivo expansion and differentiation of Lgr5-positive (Lgr5+) human intestinal stem cells and for establishment of long-term organoid cultures. Here, LGR5 is linked to adenocarcinoma.