Moreover, genes attributed to AD-associated microglial activation [23, 27] including Axl, Cst7, Itgax (encoding CD11c), Cd9 or Clec7a showed an overall increased and P2ry12 reduced expression in microglia from GF 5xFAD mice (Fig. 4B). The gene discussed is ITGAX; the disease is Alzheimer disease.