SGCG and limb-girdle muscular dystrophy: Single gene replacement strategies have been investigated in animal models for some time, primarily using adeno-associated virus (AAV) vectors that contain DNA sequences for individual LGMD genes, such as CAPN3 [84, 85], DYSF [86–89], FKRP [90–93], SGCA [94–100], SGCB [95, 101, 102], and SGCD [103–105], and SGCG [106, 107].