Subsequent studies have shown that CD147 can induce a variety of cells, including fibroblasts, endothelial cells, macrophages, tumor cells and other cells to express MMPs (MMP-1, MMP-2, MMP-3, MMP-9, MT1-MMP and MT2, etc.), leading to extracellular matrix (ECM) remodeling, and thus promoting tumor cell invasion and metastasis [19, 20]. This evidence concerns the gene MMP9 and neoplasm.