Though, CD147 was shown to induce MMP2 [42], MMP9 [41], MMP11 [43], MMP13 and MMP14 [44] in liver and our previous work proved that 3D co-culture of HCC cells and fibroblasts using matrigel enhanced CD147 expression, which in turn caused increased production of MMP2 and MMP9 [45], unexpectedly, we found that the supportive effect of CD147 on collective invasion was not abolished by a broad-spectrum MMPs inhibitor (Fig. 2) in 3D invasion model. The gene discussed is MMP9; the disease is hepatocellular carcinoma.