SULT1A1 and cancer: Our experiments, using a number of approaches and cell models, including genome-wide shRNA screen, CRISPR/Cas9-mediated SULT1A1 deletion versus its overexpression, and analysis of more than a dozen of cancer cell lines, provide a strong evidence of SULT1A1 dependence of growth suppression by three anticancer compounds, RITA, AF, and ONC-1.