RNF213 and Moyamoya disease: Its striking role in vascular development is further supported by clinical studies revealing a particular RNF213 mutant (p.R4859K, caused by a SNP of c.14576G>A) to be strongly associated with Moyamoya disease (MMD)—an occlusive cerebrovascular disorder that is marked by progressive stenosis, a concomitant formation of collateral vessels, and transient seizures [46, 47].