Of the genes with the most fusion transcript sequencing reads containing PB splice donor (implying activating insertions, see Fig. 6b), Rad51b was also a CIS gene (Fig. 6e); its fusion transcripts found in two tumors imply a putative oncogenic role, supporting data demonstrating RAD51 inhibition radio-sensitizes gliomas by reducing DNA repair [81]. The gene discussed is RAD51B; the disease is central nervous system cancer.