COL1A1 and cancer: Significant focal amplifications and deletions, identified by GISTIC2 [35], were evident in regions with known cancer genes, for example, significant focal Cdkn2a deletions (GISTIC q value = 1.39 × 10−5) were evident and EGFRvIII (in Col1a1 locus, GISTIC q value = 0.017) was recurrently amplified.