With the exception of clonal Pdgfra and Nav3 insertions in one tumor, transposon insertions in MAPK/PI3K pathway and neurodevelopmental genes (including Nf1, Pten, Pik3r1, Ptprj, Sox6, Sox5, and Tcf4) were subclonal in these tumors, implying these were late evolutionary events. The gene discussed is PIK3R1; the disease is neoplasm.