Moreover, 16 of the top 20 CIS genes had supporting fusion transcripts from at least one tumor, including Cdkn2a, Nf1, Pten, Sox6, Sox5, Spred1, and Tcf12 (all containing PB splice acceptor fusions, implying transcript termination; Fig. 6d). The gene discussed is TCF12; the disease is in situ carcinoma.