These include known tumor suppressors underlying multiple types of human gliomas, such as Cdkn2a, Nf1, and Pik3r1, as well as several putative tumor suppressors such as Sox6, Tcf12, and Spred1. However, the frequency of insertions in particular shared genes differed between brain and spinal tumors. The gene discussed is PIK3R1; the disease is neoplasm.