Genes involved in the PI3K-AKT oncogenic pathway were also identified including known tumor suppressor genes in gliomas such as Pten [70] and Pi3kr1 [71] as well as novel genes including Prex2, and the protein tyrosine phosphatases Ptpro and Ptprj, all with inactivating transposon insertional patterns. Here, PTPRO is linked to central nervous system cancer.