Recurrent deletions in previously unknown glioma genes NT5C2, ADGRL2, and UIMC1 were observed whilst SUB1, CES1, and ITGA6 were frequently methylated in human LGGs (Additional file 1: Fig. S10); frequent CNVs in these genes were also present in human GBMs. The gene discussed is CES1; the disease is central nervous system cancer.