Genes involved in the PI3K-AKT oncogenic pathway were also identified including known tumor suppressor genes in gliomas such as Pten [70] and Pi3kr1 [71] as well as novel genes including Prex2, and the protein tyrosine phosphatases Ptpro and Ptprj, all with inactivating transposon insertional patterns. This evidence concerns the gene PTPRJ and central nervous system cancer.