These IHC results complied with the fundus fluorescein angiography and HE results, and CD31 served as a biomarker of ECs (as a part of neovascularization), it can be inferred that retinal neovascularization was inhibited in the OIR+ endostatin-lentivirus and OIR+ endostatin-lentivirus-EPC groups. This evidence concerns the gene COL18A1 and hereditary elliptocytosis.