When modeled jointly, the effect of the peptide LQAHLVAQTNLLR on cognitive decline is reduced significantly (from r2 = 1.48% to r2 = 0.49%), whereas the effect of tangles on cognitive decline is unchanged (from r2 = 20% to r2 = 19.7%), suggesting that the majority of the role of BIN1 in cognitive decline is not independent of tangles (Suppl.Table.9). Here, BIN1 is linked to Mental deterioration.