BIN1 and Alzheimer disease: While the number of BIN1 exon 7+ neurons shows no difference between the two sets of subjects (with a total of 9735 neurons assessed in our 7 subjects) (Fig. 6a), we find, in the same individuals, a significant decrease in the number of astrocytes expressing BIN1 exon 7 in AD compared to cognitively non-impaired subjects (a total of 14,643 astrocytes were evaluated), while there is not a significant difference in the total number of astrocytes between the two classes of subjects (Fig. 6b).