Obesity negatively impacted the sWAT-MSC secretome, since its anti-oxidant (GCL, Prdx5, Prdx6) and tissue development (Ang, Angptl4, Fstl3, Pgf) activities were lost, while factors promoting osteoporosis and negative vessel remodeling were acquired. This evidence concerns the gene ANG and obesity due to melanocortin 4 receptor deficiency.