Obesity negatively impacted the sWAT-MSC secretome, since its anti-oxidant (GCL, Prdx5, Prdx6) and tissue development (Ang, Angptl4, Fstl3, Pgf) activities were lost, while factors promoting osteoporosis and negative vessel remodeling were acquired. Here, PRDX6 is linked to osteoporosis.