Obesity negatively impacted sWAT-MSC secretome: the anti-oxidant (GCL, Prdx5, Prdx6) and tissue development (Ang, Angptl4, Fstl3, Pgf) activities were lost, while factors promoting osteoporosis and negative vessel remodeling were acquired. This evidence concerns the gene ANG and obesity due to melanocortin 4 receptor deficiency.