Although EXOC3L2 rs10406604 and CD3EAP rs3212986 did not meet the GWAS statistical significance (P value < 5.0E-8), they showed statistical significance (1.94E-4 and 8.58E-05) and the haplotype including 2 SNPs provided a better model to show a more significant association with lipid profiles and cardiovascular diseases risk. The gene discussed is EXOC3L2; the disease is cardiovascular disorder.