SFTPB and hyperinsulinemic hypoglycemia, familial, 4: Several genes associated with monogenetic lung disorders were also dysregulated in specific cell populations of smokers, including PCD (OFD1 – down-regulated in ciliated cells) and surfactant deficiency (SFTPB - up-regulated in ionocytes)-related genes (Fig. 5a, e, Supplemental Table S8).