CCN2 and myocardial infarction: Ultimately, in the necrotic myocardium, upregulation of TNF-α (Fig. 6h) and deregulation of BSG were observed 1 week after MI induction, whereas levels of TNF-α, CTGF (Fig. 6i), and TGF-β (Fig. 6j) were elevated after 1 month.