TP53 and neoplasm: One possible reason for this is that the 16-bp Ins allele (duplication, A2A2) leads to lower level of p53 transcript, suggesting that extra-long polymorphisms are likely to cause an alteration in the processing of messenger RNA (mRNA), to the extent of even being translated into a defective protein, leading to a decrease in the p53-mediated apoptosis of tumor cells [38, 39].