No significant correlation of HPD was found with age > 65 years, gender, smoking history, neutrophil-to-lymphocyte ratio, PD1/PD-L1, PD-L1 status, monotherapy/combination, number of previous treatment lines, pathological pattern in NSCLC, EGFR mutation, KRAS mutation, or ALK rearrangement in NSCLC. The gene discussed is ALK; the disease is non-small cell lung carcinoma.