Aiming at the improvement of early CKD detection, the Kidney Disease Outcomes Quality Initiative (K/DOQI) of the National Kidney Foundation published clinical practice guidelines recommending the use of estimating equations of GFR on the basis of serum creatinine determinations and Urinary-Albumin-Creatinine-Ratio (UACR) [12, 13]. This evidence concerns the gene ALB and kidney disorder.