Molecular pathways involved in mesothelioma cell lines showed that caspase 3 and 4 are activated, but not caspase 8 and 9, suggesting that HUHS1015 induced apoptosis not through canonical extrinsic and intrinsic pathways but perhaps through reticulum stress (known to activate apoptosis through caspase 4) or through independent-caspase pathway [93]. Here, CASP3 is linked to mesothelioma.