Like naftopidil in mesothelioma cells, HUHS1015 also increased expression of factors implicated in the extrinsic apoptosis pathway, such as the cytokine TNF-α in MKN45 gastric cells; however, this effect has been called into question due to the very high concentrations of HUHS1015 used [63,94]. Here, TNF is linked to mesothelioma.