Moreover, it was shown to induce apoptosis of mesothelioma cells NCI-H28, NCI-H2052, NCI-2452 and MSTO-211H by activating caspase 3 and 8 [63,64] and increasing TNF-α mRNA expression and Fas-Ligand secretion in NCI-H2052 however, this effect is only observed for high concentrations. This evidence concerns the gene TNF and mesothelioma.