Exosomes derived from pancreatic cancer cells promote hypoxia-inducible factors (HIF)-1α/HIF-2α-dependent M2 phenotype through PTEN regulation: miR-301a-3p converts stromal macrophages into M2 macrophages and promotes lung metastases formation by blocking PTEN transcription [87]. This evidence concerns the gene PTEN and familial pancreatic carcinoma.