Moreover, PTEN heterozygous (PTEN+/−) mice are deficient in Fas-mediated apoptosis: as the binding of Fas (also known as CD95) to its ligand (FasL) is the main mechanism by which CD8+ cytotoxic T-cells kill non-self-cancer cells, PTEN haploinsufficiency results in lymphoid hyperplasia and tumor growth [58,59]. Here, CD8A is linked to neoplasm.