This data, together with the induction of apoptosis, inhibition of α5 translocation and low adhesion on ECM, reduction in cell migration and integrin α5 expression, allowed us to suggest a contribution of the mixture in restoring anoikis sensitivity in human astrocytoma cells through epigenetic regulation and the functional reduction in the p53 oncogenic isoform responsible for the aggressive and invasive nature of this tumor. Here, TP53 is linked to neoplasm.