Among the different valuable nutrients, sulforaphane (SFN) has largely demonstrated its beneficial potentiality in prevention and in multistage cancer development, by affecting important cellular mechanisms including the epigenetic pathway modulation, the sensitivity restoration to anoikis in some cancer cell types and animal models, the alteration in cell cycle control with p21 up-regulation and a block in the PI3K/Akt signaling pathway [12,15,21,22,34]. The gene discussed is CDKN1A; the disease is cancer.