In particular, the analysis of blood vessel tension clearly indicated that ginseng had a vasodilation effect through activation of endothelial nitric oxide synthase (eNOS) and the inhibition of ACE and angiotensin II activities [29,30], which are related to hypertension; however, the effects of ginseng and individual compounds on eNOS activity were not investigated in the present study. This evidence concerns the gene NOS3 and hypertensive disorder.