STAT3 and breast carcinoma: Ma et al. demonstrated that DMU-212 exerts higher growth inhibition in breast cancer cell lines: MCF-7 and MDA-MB-435 by block cell cycle at G2/M phase, decrease Cyclin D1 expression and inhibition signal transducer and activator of transcription 3 (STAT3) phosphorylation, which may impact tubulin polymerization [96].