ITGAM and neoplasm: In a previously reported mouse model injected with breast cancer cell line (4T1), among the recruited bone marrow-derived CD11b+Gr1+ myeloid progenitor cells in premetastatic lung, CD11b+Ly6Chigh monocytic MDSCs secreted versican, an extracellular matrix proteoglycan, thus triggering the EMT, increases tumor cell proliferation, and accelerates metastasis [149].