TAM-derived IL-10 display increased expression of bcl-2 and STAT3 genes, and the subsequent IL-10/STAT3/Bcl-2 signaling pathway induced TAM-mediated treatment resistance on co-culturing human breast cancer cell lines (T47D, BT549) and TAMs (THP-1) [111]. The gene discussed is STAT3; the disease is breast carcinoma.