Considering that EGFR over-expression is prevalent in PDAC and HNSCC, we compared the NIR phototoxicity of Cet-PINs with TR-PINs (specific for the additional receptors HER-2 and TfR) in the MIA PaCa-2 and SCC-9 3D nodules. This evidence concerns the gene ERBB2 and head and neck squamous cell carcinoma.