EGFR and pancreatic ductal adenocarcinoma: We have recently shown for the first time that our chemically tuned NIR light-activated Cet-PINs targeted to a single receptor, EGFR, selectively binding, permeating, and destroying tumor cells in a 3D heterocellular pancreatic ductal adenocarcinoma (PDAC) model more efficiently than untargeted-PSNs [65].