EGFR and cancer: Several approaches have been recently tested: the use of inhibitors of the EGFR/mTOR/HIF-1 (epidermal growth factor receptor/mammalian target of rapamycin/hypoxia inducible factor-1) signaling pathway, such as cetuximab [6], the use of silica nanoparticles to deliver hypoxia-activated prodrugs such as tirapazamine [7], the development of nitroimidazole analogues [8], HSP90 inhibitor such as ganetespib [9] or the identification of miRNAs secreted by hypoxic cancer cells [10].