BRCA2 and cancer: Recommendations for the known high risk genes, BRCA1 and BRCA2, include increased breast awareness and screening, discussion of risk-reducing mastectomy and/or bilateral-salpingo oophorectomy, education about cancer signs and symptoms and genetic counselling (see The National Comprehensive Cancer Network (NCCN) Guidelines for Genetic/Familial High-Risk Assessment: Breast, Ovarian, and Pancreatic Cancer, Version 1.2020).