Interestingly, tumor tissues from MKN45-SCD1 mice showed a significantly increased number of Twist1+ and Ki67+ cells, indicating SCD1 enhanced proliferation and metastasis as compared with tumor tissues from control ones (MKN45-Vector: 84.200 ± 2.478, MKN45-SCD1: 179.400 ± 2.926, P <0.0001; Figure 5D, 5E). This evidence concerns the gene TWIST1 and neoplasm.