It also drives detrimental autoinflammation, sepsis, and non-alcoholic steatohepatitis (NASH) by promoting passive secretion of interleukin-1β (IL-1β) and alarmins (Kanneganti et al., 2018; Xiao et al., 2018; Xu et al., 2018). Here, IL1B is linked to metabolic dysfunction-associated steatohepatitis.