The inflammation and spontaneous autoimmunity caused by PTPN2 deficiency in T cells can therefore be attributed to self-antigen-mediated increases in TCR sensitivity and the enhanced responses to common γ-chain cytokines (Fukushima et al., 2010; Wiede et al., 2011, 2014a; Zikherman and Weiss, 2011). This evidence concerns the gene PTPN2 and Autoimmunity.