PTPN2 and Autoimmunity: A T cell-specific deletion of PTPN2 promotes the development of systemic inflammation and autoimmunity in otherwise non-autoimmune-prone C57BL/6 mice and accelerates the onset of type 1 diabetes in autoimmune-prone non-obese diabetic (NOD) mice (Wiede et al., 2011, 2019; Zikherman and Weiss, 2011).