The importance of mTORC1 in DKD pathophysiology is amply emphasized by the fact that moderate changes in RPTC mTORC1 activity were sufficient to exert robust effects on fibrosis: deletion of a single Tsc1 allele induced fibrogenesis, whereas partial deletion of Raptor prevented diabetes-induced renal fibrosis. This evidence concerns the gene TSC1 and renal fibrosis.