SLC5A2 and diabetes mellitus: In diabetes, the sodium reabsorption workload on RPTCs is increased by hyperglycemia, most likely via increased SGLT2 expression in these cells (Wang et al., 2017; Rahmoune et al., 2005; Vestri et al., 2001), which in turn elevates the glomerular filtration of glucose followed by its reuptake in RPTCs (Gilbert, 2017).