ISGs positively potentiating IFN signaling, such as IFIH1/MDA5, TANK, IRF7, and STAT1, were also increased in the bronchoalveolar lavage fluid (BALF) of COVID-19 patients as compared with healthy controls [105] and could potentially contribute to the amplification of IFN-I response against SARS-CoV-2 replication. This evidence concerns the gene IFIH1 and COVID-19.