Although it has been reported that LSD1 can regulate p53 by removing both monomethoxylation (k370me1) and dimerization (k370me2) at k370 [30], it has been reported that the expression of p53 is not related to LSD1 in CRC tissue [17].In our study, p53 was correlated with LSD2 function in CRC. This evidence concerns the gene TP53 and colorectal carcinoma.