Genome‐wide linkage analysis studies identified nine “Psoriasis Susceptibility” regions or loci (PSORS1‐9: #177900, #602723, %601454, %603935, % 604316, % 605364, %10706, %610707, %607857) including identification of CARD14 as being the responsible gene for the underlying association of the PSORS2 locus with psoriasis. The gene discussed is HLA-C; the disease is psoriasis.