In GC, miRNAs have been found to play various regulatory roles in cell PLF, MGT, multidrug resistance, etc For example, miR‐4268 represses the PLF of GC cells by targeting Rab6B27; miR‐107 modulates the growth and MGT of GC cells by down‐regulating FAT4 to activate PI3K‐AKT signaling pathway28; miR‐200c reverses the cisplatin resistance of GC by targeting NER‐ERCC3/4.29 This evidence concerns the gene AKT1 and gastric cancer.