To investigate the interaction between HCG18 and miR‐141‐3p, as well as their roles in regulating the progression of GC, miR‐141‐3p was highly expressed in GC cells overexpressing HCG18, and miR‐141‐3p was inhibited in GC cells with HCG18 knockdown. This evidence concerns the gene HCG18 and gastric cancer.