Here, the authors found recurrent promoter methylation in ITAC of the genes CDH13, ESR1, APC, TIMP3, CASP8, HIC1 and RASSF1. Interestingly, TIMP3 methylation correlated with worse survival, which has been similarly demonstrated in gastric, colon, prostate and hepatic adenocarcinoma, indicating that epigenetic regulation of this gene may be an important driver in the carcinogenesis of this tumour type. The gene discussed is TIMP3; the disease is neoplasm.