In another study of large public datasets of the KRAS mutant lung adenocarcinoma [32], three subtypes were observed based on gene expression signatures, which were also characterized by different co-mutations, i.e., cluster1/CDKN2A/2B-mutant/LOH, cluster 2/TP53 mutant, and cluster3/LKB1 mutant (Table 3). Here, TP53 is linked to lung adenocarcinoma.