Aggregates of the protein tau are the hallmark of several neurodegenerative diseases including Alzheimer’s disease, frontotemporal lobar degeneration (FTLD-tau), progressive supranuclear palsy (PSP), corticobasal degeneration (CBD), Pick’s disease, and chronic traumatic encephalopathy (CTE) (VandeVrede, Boxer et al. 2020). The gene discussed is MAPT; the disease is early-onset autosomal dominant Alzheimer disease.