Nakamura et al26 reported that hypermutated cases, where the high mutation load created abundant tumor‐specific neoantigens, were significantly enriched in immune checkpoint genes (cluster 4); they also evaluated the expression of nine targetable immunosuppressive immune checkpoint molecules, including PD‐L1 (CD274), and the expression of these molecules was significantly higher in cluster 4 than in other clusters. This evidence concerns the gene CD274 and neoplasm.