Remarkably, several complement regulator genes (CD59, CD46, CD55, CLUSTERIN, VITRONECTIN, CFH, and CFHR1-4) were upregulated in inferior turbinates compared to nasal polyps, whereas some genes were increased in polyps, such as genes coding for complement receptors (CR1, CR4, CRIG); others only showed a slight increase for polyps as genes coding for the central cascade (C3, C4, C5, C6, C8). Here, C4A is linked to Nasal polyposis.