Although alone the acupuncture protocol with ST36 or GB34 could not significantly inhibit LPS-mediated NF-κB activation, the electroacupuncture protocol with ST36+GB34 decreased the LPS level in synovial fluid and inhibited the phosphorylation of NF-κB p65 in arthrodial cartilage of obesity rats. Here, NFKB1 is linked to obesity due to melanocortin 4 receptor deficiency.