RHOA and infarction: Moreover, in local cerebral infarction, RhoA expression in ischemic brain tissue began to increase at 6 h after infarction and peaked at 24 h [9], which was much earlier than what was observed by Fard et al. It is known that the ON is part of the white matter of the brain, so it is reasonable to hypothesize that this early expression pattern of RhoA in ON infarction is similar to that in cerebral infarction.