ADIPOQ and Insulin resistance: Adiponectin is secreted exclusively in adipose tissue and is responsible for inducing insulin resistance to regulate the oxidation of fatty acids (Havel, 2002; You, Considine, Leone, Kelly, & Crabb, 2005), which may help maintain lipogenesis during the hyperphagia when bears need to store fat, whereas the decrease during hibernation that generates insulin resistance facilitates the switch to a lipolytic metabolism (Kadowaki et al., 2006).